Background: A considerable proportion of children with early-life overweight attain a normal weight. To recognize infants at risk of persistent overweight, we compared earlylife factors of children with a longitudinal pattern of persistent overweight to children with a pattern of overweight in early but not in later childhood. Methods: In 3,550 children participating in a birth cohort that started in 1996/1997 in the Netherlands, body mass index was repeatedly assessed until age 11 and dichotomized into with/without overweight. Latent class growth modeling was used to distinguish trajectories. Our analysis was focused on the comparison of early-life factors in children in a persistent overweight pattern with those in an overweight reduction pattern using multivariable log-binomial regression analyses. Results: Children (n = 133) in the persistent overweight pattern were more likely to have overweight parents [relative risk (RR) mother : 1.85, 95% CI: 1.37-2.49: RR father : 1.75, 95% CI: 1.21- 2.55] than children in the overweight reduction pattern (n = 303). Maternal education, child's gender, ethnicity, birth weight, breast-feeding and maternal smoking during pregnancy did not differ between the trajectories. Conclusion: Health care practitioners should focus on high-weight infants with overweight parents, as these children are less likely to resolve their overweight.

Birth cohort, Early life determinants, Epidemiology, Latent class growth curve, Overweight, Trajectory,
Annals of Nutrition and Metabolism
Department of Pediatrics

van Rossem, L, Wijga, A.H, Brunekreef, B, de Jongste, J.C, Kerkhof, M, Postma, D.S, … Smit, H.A. (2014). Overweight in infancy: Which pre- and perinatal factors determine overweight persistence or reduction? A birth cohort followed for 11 years. In Annals of Nutrition and Metabolism (Vol. 65, pp. 211–219). doi:10.1159/000360305