Background: Asthma guidelines recommend monitoring of asthma control. However, in a substantial proportion of children, asthma is poorly controlled and the best monitoring strategy is not known. Objectives: We studied two monitoring strategies for their ability to improve asthma outcomes in comparison with standard care (SC): web-based monthly monitoring with the (Childhood) Asthma Control Test (ACT or C-ACT) and 4-monthly monitoring of FE<inf>NO</inf>. Methods: In this randomised controlled, partly blinded, parallel group multicentre trial with a 1-year follow-up, children aged 4-18 years with a doctor's diagnosis of asthma treated in seven hospitals were randomised to one of the three groups. In the web group, treatment was adapted according to ACT obtained via a website at 1-month intervals; in the FE<inf>NO</inf> group according to ACT and FE<inf>NO</inf>, and in the SC group according to the ACT at 4-monthly visits. The primary endpoint was the change from baseline in the proportion of symptom-free days (SFD). Results: Two-hundred and eighty children (mean age 10.4 years, 66% boys) were included; 268 completed the study. Mean changes from baseline in SFD were similar between the groups: -2.1% (web group, n=90), +8.9% (FE<inf>NO</inf> group, n=91) versus 0.15% (SC, n=87), p=0.15 and p=0.78. Daily dose of inhaled corticosteroids (ICS) decreased more in the web-based group compared with both other groups (-200 μg/day, p<0.01), while ACT and SFD remained similar. Conclusions: The change from baseline in SFD did not differ between monitoring strategies. With web-based ACT monitoring, ICS could be reduced substantially while control was maintained.

dx.doi.org/10.1136/thoraxjnl-2014-206161, hdl.handle.net/1765/86331
Thorax: an international journal of respiratory medicine
Department of Bioinformatics

Voorend-van Bergen, T.A.S, Vaessen-Verberne, A.A.P.H, Brackel, H.J.L, Landstra, A.M, van den Berg, N.J, Hop, W.C.J, … Pijnenburg, M.W.H. (2015). Monitoring strategies in children with asthma: A randomised controlled trial. Thorax: an international journal of respiratory medicine, 70(6), 543–550. doi:10.1136/thoraxjnl-2014-206161