Purpose: Previous studies have suggested a link between Q fever and uveitis. We determined whether Coxiella burnetii causes intraocular infection in C. burnetii-seropositive patients with idiopathic uveitis. Methods: From a retrospective observational case series, paired aqueous humor and serum samples from 10 C. burnetii-seropositive patients with idiopathic uveitis were examined for intraocular antibody production by using the Goldmann-Witmer coefficient and by polymerase chain reaction (PCR). Results: Although intraocular IgG against C. burnetii was detected, no intraocular antibody production was observed (low Goldmann Wittmer coefficients). All PCR results were negative. Conclusions: Uveitis due to an intraocular infection with C. burnetii is unlikely.

Aqueous humor analysis, Coxiella burnetii, infection, uveitis
dx.doi.org/10.3109/09273948.2014.925123, hdl.handle.net/1765/86407
Ocular Immunology and Inflammation
Department of Internal Medicine

Hermans, L.E, Oosterheert, J.J, Kampschreur, L.M, Ossewaarde-Van Norel, J, Dekkers, J, Rothová, A, & de Groot-Mijnes, J.D.F. (2016). Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis. Ocular Immunology and Inflammation, 24(1), 77–80. doi:10.3109/09273948.2014.925123