Aging: Not all DNA damage is equal
Current Opinion in Genetics & Development , Volume 26 p. 124- 130
Recent advances have identified accumulation of DNA damage as a major driver of aging. However, there are numerous kinds of DNA lesions each with their own characteristics and cellular outcome, which highly depends on cellular context: proliferation (cell cycle), differentiation, propensity for survival/death, cell condition and systemic hormonal and immunological parameters. In addition, DNA damage is strongly influenced by cellular metabolism, anti-oxidant status and exogenous factors, consistent with the multi-factorial nature of aging. Notably, DNA lesions interfering with replication have very different outcomes compared to transcription. These considerations provide a conceptual framework in which different types of DNA damage and their setting contribute to the aging process in differential manners.
|Current Opinion in Genetics & Development|
|Organisation||Department of Molecular Genetics|
Vermeij, W.P, Hoeijmakers, J.H.J, & Pothof, J. (2014). Aging: Not all DNA damage is equal. Current Opinion in Genetics & Development (Vol. 26, pp. 124–130). doi:10.1016/j.gde.2014.06.006