Prostate cancer is diverse in clinical presentation, histopathological tumor growth patterns, and survival. Therefore, individual assessment of a tumor's aggressive potential is crucial for clinical decision-making in men with prostate cancer. To date a large number of prognostic markers for prostate cancer have been described, most of them based on radical prostatectomy specimens. However, in order to affect clinical decision-making, validation of respective markers in pretreatment diagnostic needle-biopsies is essential. Here, we discuss established and promising histopathological and molecular parameters in diagnostic needle-biopsies.

doi.org/10.1155/2014/341324, hdl.handle.net/1765/86614
BioMed Research International
Department of Pathology

Hoogland, A.M, Kweldam, C.F, & Leenders, G.J.H.L. (2014). Prognostic Histopathological and Molecular Markers on Prostate Cancer Needle-Biopsies: A Review. BioMed Research International (Vol. 2014). doi:10.1155/2014/341324