An infertile couple was referred for intracytoplasmic sperm injection (ICSI) because of primary infertility and oligoasthenoteratozoospermia (OAT) in the male. It was observed that although the sperm cells presented with an unusual head size and multiple tails they were able to fertilize the oocytes after ICSI. Subsequent molecular cytogenetic analysis demonstrated de-novo chromosome abnormalities in virtually all sperm cells with 40% diploidy and 24% triploidy in addition to aneuploidy for the sex chromosomes.

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Human Reproduction
Erasmus MC: University Medical Center Rotterdam

in 't Veld, P. A., Broekmans, F., de France, H. F., Pearson, P. L., Pieters, M. H., & van Kooij, R. J. (1997). Intracytoplasmic sperm injection (ICSI) and chromosomally abnormal spermatozoa. Human Reproduction. Retrieved from