Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min-1). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min-1); 18.5 ± 1.5 (5 L min-1); 21.7 ± 1.7 (10 L min-1); 24.0 ± 2.3 (15 L min-1). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min-1 appears to be more effective than 5 or 10 L min-1. Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

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doi.org/10.1186/s40001-015-0194-5, hdl.handle.net/1765/87130
European Journal of Medical Research
Department of Rehabilitation Medicine

Rozenberg, R., Mankowski, R. T., van Loon, L., Langendonk, J., Sijbrands, E., van den Meiracker, A., … Praet, S. (2016). Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study. European Journal of Medical Research, 21(1). doi:10.1186/s40001-015-0194-5