2016
Release of growth-differentiation factor 15 and associations with cardiac function in adult patients with congenital heart disease
Publication
Publication
International Journal of Cardiology , Volume 202 p. 246- 251
Background: Growth-differentiation factor-15 (GDF-15), a cytokine with broad cardiac and non-cardiac activity, has diagnostic and prognostic value in various diseases, including heart failure. We aimed to investigate the release of GDF-15 in adults with congenital heart disease (ConHD), and assess the association with cardiac function and functional capacity.
Methods: A total of 587 consecutive adults with ConHD underwent electrocardiography, echocardiography, venepuncture and were seen by a cardiologist. A subset of 143 patients underwent bicycle ergometry on the same day.
Results: Median plasma GDF-15 was 618 ng/L. In 87 patients, GDF-15 was above the reference value of normal. GDF-15 levels were higher in older patients. GDF-15 was higher in patients with elevated pulmonary pressure. In multivariate analysis adjusting for age, sex, and NT-proBNP, hs-TnT and hs-CRP, GDF-15 above the reference value was associated with NYHA class, and decreased exercise capacity, but not with systolic ventricular function or ECG rhythm.
Conclusions: GDF-15 is elevated in a substantial number of patients and higher in those with elevated pulmonary pressures, regardless of underlying congenital diagnosis. GDF-15 is associated with NYHA class, NT-proBNP and exercise capacity, suggesting the marker has diagnostic and potential prognostic value in adults with ConHD.
Additional Metadata | |
---|---|
, , , | |
doi.org/10.1016/j.ijcard.2015.09.010, hdl.handle.net/1765/87168 | |
International Journal of Cardiology | |
Organisation | Department of Cardiology |
Eindhoven, J., van den Bosch, A., Oemrawsingh, R., Baggen, V., Kardys, I., Cuypers, J., … Boersma, E. (2016). Release of growth-differentiation factor 15 and associations with cardiac function in adult patients with congenital heart disease. International Journal of Cardiology, 202, 246–251. doi:10.1016/j.ijcard.2015.09.010 |