A 69-year-old woman had a progressive demyelinating and axonal polyneuropathy and a monoclonal gammopathy. Physical examination showed hyperpigmentation, acrocyanosis, white nails and pitting oedema. Additional tests showed polycythemia, thrombocytosis, a high serum VEGF-level, clonal plasma cells on bone marrow biopsy and sclerotic lesions of a cervical rib and the cervical and thoracal spine. POEMS-syndrome was diagnosed.

Nederlands Tijdschrift voor Geneeskunde
Erasmus MC: University Medical Center Rotterdam

Van Der Meijden, W. A. G., Alsma, J., & van Doorn, P. (2014). A woman with polyneuropathy and white nails. Nederlands Tijdschrift voor Geneeskunde, 158(18). Retrieved from http://hdl.handle.net/1765/87198