Intrahepatic cholestasis of pregnancy is a cholestatic disorder with an increased risk for adverse perinatal outcome. The mechanism underlying intrauterine demise is poorly understood.A nulliparous woman with gestational age of 36 plus 6 weeks presented with suspected intrahepatic cholestasis. Continuous CTG monitoring evolved from a normal pattern towards a non-reassuring pattern. A male neonate was delivered by caesarean section. Apgar scores 0, 1 and 4 at 1, 5 and 10 min. Fetal cord gas analysis showed pH 6.98, base deficit –15 mmol/L. Blood results showed maternal serum bile acid concentration of 220 mmol/L.Our case suggests gradual evolution towards hypoxia and acidosis. It is unknown whether certain components in the bile acid concentrations might contribute to a fetal metabolic component of the acidosis.

complications, High-risk pregnancy,
Obstetric Medicine
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Department of Gynaecology & Obstetrics

Sterrenburg, K, Visser, W, Smit, L, & Cornette, J.M.J. (2014). Acidosis: A potential explanation for adverse fetal outcome in intrahepatic cholestasis of pregnancy. A case report. Obstetric Medicine, 7(4), 177–179. doi:10.1177/1753495X14553649