In recent years, several technical developments in the field of cardiac computed tomography (CT) have made possible the extraction of functional information from an anatomy-based examination. Several different lines have been explored and will be reviewed in the present paper, namely: 1) myocardial perfusion imaging; 2) transluminal attenuation gradients and corrected coronary opacification indexes; 3) fractional flow reserve computed from CT; and 4) extrapolation from atherosclerotic plaque characteristics. In view of these developments, cardiac CT has the potential to become in the near future a truly 2-in-1 noninvasive evaluation for coronary artery disease.

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JACC: Cardiovascular Imaging
Department of Cardiology

de Araújo Gonçalves, P., Rodriguez-Granillo, G., Spitzer, E., Suwannasom, P., Loewe, C., Nieman, K., & Garcia-Garcia, H. (2015). Functional evaluation of coronary disease by CT angiography. JACC: Cardiovascular Imaging, 8(11), 1322–1335. doi:10.1016/j.jcmg.2015.09.003