Darapladib for the treatment of cardiovascular disease
Expert Review of Cardiovascular Therapy , Volume 13 - Issue 1 p. 33- 48
Elevated levels of phospholipase A2 have been linked to atherosclerotic plaque progression, instability via promoting inflammation and subsequent acute coronary events. Epidemiological studies have demonstrated the correlation between elevated levels associated phospholipase A2 and cardiovascular events. Therefore, specific inhibition of lipoprotein-associated phospholipase A2 with darapladib has been tested as a therapeutic option for atherosclerosis. The aim of this profile is to review the physiologic aspects of lipoprotein-associated phospholipase A2 and to revisit the clinical evidence of darapladib as therapeutic option for atherosclerosis.
|atherosclerosis, darapladib, inflammation, phospholipase A2|
|Expert Review of Cardiovascular Therapy|
|Organisation||Department of Cardio-Thoracic Surgery|
Campos, C.A.M, Suwannasom, P, Koenig, W, Serruys, P.W.J.C, & Garcia-Garcia, H.M. (2015). Darapladib for the treatment of cardiovascular disease. Expert Review of Cardiovascular Therapy (Vol. 13, pp. 33–48). doi:10.1586/14779072.2015.986466