In the past decade, hybrid single photon emission computed tomography (SPECT)/coronary computed tomography angiography (CCTA) has been demonstrated as an accurate diagnostic technique in patients suspected of significant coronary artery disease (CAD). With this combination of anatomical and functional imaging of CAD, negative and positive predictive values over 95 % were reported. The current review provides an update of recent literature on diagnostic accuracy and will position hybrid SPECT/CCTA imaging at the end of a non-invasive imaging cascade to virtually leave no diagnostic uncertainty about the presence or absence of significant CAD. Moreover, hybrid SPECT/CCTA was evaluated for its use in the process of clinical decision-making in a study that made a head-to-head comparison of actual treatment decisions based on hybrid SPECT/CCTA and routine coronary angiography. As such, the role of hybrid SPECT/CCTA in the current work-up of patients presenting with anginal complaints will be evaluated.

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Current Cardiovascular Imaging Reports
Department of Nuclear Medicine

Kauling, R., Post, M., Rensing, B., Verzijlbergen, F., & Schaap, J. (2015). Hybrid SPECT/CCTA Imaging in the Work-up of Patients with Suspected Coronary Artery Disease. Current Cardiovascular Imaging Reports (Vol. 8). doi:10.1007/s12410-014-9316-7