Purpose: To determine the long-term impact of stereotactic radiotherapy (SRT) on the quality of life (QoL) of inoperable patients with early-stage non-small cell lung cancer (NSCLC). Methods and materials: From January 2006 to February 2008, 39 patients with pathologically confirmed T1-2N0M0 NSCLC were treated with SRT. QoL, overall survival and local tumor control were assessed. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30 and the lung cancer-specific questionnaire QLQ-LC13 were used to investigate changes in QoL. Assessments were done before treatment, at 3weeks, every 2-3 months during the first two years, and then every 6months until 5years after the treatment or death or progressive disease. The median follow up was 38months. Results: During the 5years after treatment with SRT for stage I NSCLC, the level of QoL was maintained: There was a slow decline (slope: - 0.015) of the global health status over the 5years (p < 0.0001). The physical functioning and the role functioning improved slowly (slope: 0.006 and 0.004, resp.) over the years and this was also significant (p < 0.0001). The emotional functioning (EF) improved significantly at 1year compared to the baseline. Two years after the treatment dyspnea slowly increased (slope: 0.005, p = 0.006). The actuarial overall survival was 62% at 2years and 31% at 5-years. Conclusion: QoL was maintained 5years after SRT for stage I NSCLC and EF improved significantly. Dyspnea slowly increased 2years after the treatment.

dx.doi.org/10.1186/s13014-015-0405-9, hdl.handle.net/1765/87552
Radiation Oncology
Department of Pulmonology

Ubels, R.J, Mokhles, S, Andrinopoulou, E-R, Braat, C, van der Voort van Zyp, N.C.M-G, Aluwini, S, … Nuyttens, J.J.M.E. (2015). Quality of life during 5 years after stereotactic radiotherapy in stage I non-small cell lung cancer. Radiation Oncology, 10(1). doi:10.1186/s13014-015-0405-9