• All NSAIDs may induce cardiotoxicity. In this respect naproxen is relatively the safest choice. • Selective cyclo-oxygenase-2-inhibitors (coxibs) are at least as effective in preventing clinically relevant gastrointestinal toxicity as non-selective NSAIDs plus a protonpump inhibitor (PPI). • Non-selective NSAIDs plus a PPI are more effective in prevention of dyspepsia than coxibs. • After a serious gastrointestinal complication while using NSAIDs, in principal the patient should no longer use NSAIDs. If needed, a coxib plus a PPI is the first choice.

Nederlands Tijdschrift voor Geneeskunde
Erasmus MC: University Medical Center Rotterdam

van den Bemt, P., Tjwa, E., & van Oijen, M. (2014). Cardiovascular and gastrointestinal safety of NSAIDs. Nederlands Tijdschrift voor Geneeskunde, 158(16). Retrieved from http://hdl.handle.net/1765/87594