Human herpes virus 8 (HHV-8)-associated secondary hemophagocytic lymphohistiocytosis is a rare but critical immuno-hematological entity in immunocompetent patients. Establishing a diagnosis is challenging as is the monitoring of disease activity and therapeutic effects. We report a case of a HHV-8-associated hemophagocytic lymphohistiocytosis in a HIV-negative adult patient with multicentric Castleman’s disease. As a novel finding, we report the use of certain inflammatory parameters, primarily interleukin-10 combined with viral load monitoring of the causative infectious agent in this case HHV-8 to monitor the clinical course of the hemophagocytic lymphohistiocytosis in the setting of bacterial septic complications.

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Keywords Hemophagocytic lymphohistiocytosis, Human herpes virus 8, Interleukin-10, Multicentric Castleman’s disease
Persistent URL dx.doi.org/10.1007/s12185-015-1928-4, hdl.handle.net/1765/87766
Journal International Journal of Hematology
Citation
Zondag, T.C.E, Rokx, C, van Lom, K, van den Berg, A.R, Sonneveld, P, Dik, W.A, … van Laar, J.A.M. (2016). Cytokine and viral load kinetics in human herpesvirus 8-associated multicentric Castleman’s disease complicated by hemophagocytic lymphohistiocytosis. International Journal of Hematology, 103(4), 469–472. doi:10.1007/s12185-015-1928-4