We have prepared this document, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update", according to the evidence-based criteria, revising and updating chapters of the originally published paper, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2009", available at. Namely, these comprise: "Mechanisms of sublingual immunotherapy;" "Clinical efficacy of sublingual immunotherapy" - reporting all the data of all controlled trials published after 2009; "Safety of sublingual immunotherapy" - with the recently published Grading System for adverse reactions; "Impact of sublingual immunotherapy on the natural history of respiratory allergy" - with the relevant evidences published since 2009; "Efficacy of SLIT in children" - with detailed analysis of all the studies; "Definition of SLIT patient selection" - reporting the criteria for eligibility to sublingual immunotherapy; "The future of immunotherapy in the community care setting"; "Methodology of clinical trials according to the current scientific and regulatory standards"; and "Guideline development: from evidence-based medicine to patients' views" - including the evolution of the methods to make clinical recommendations. Additionally, we have added new chapters to cover a few emerging crucial topics: "Practical aspects of schedules and dosages and counseling for adherence" - which is crucial in clinical practice for all treatments; "Perspectives and new approaches" - including recombinant allergens, adjuvants, modified allergens, and the concept of validity of the single products. Furthermore, "Raising public awareness about sublingual immunotherapy", as a need for our patients, and strategies to increase awareness of allergen immunotherapy (AIT) among patients, the medical community, all healthcare stakeholders, and public opinion, are also reported in detail.

Allergen-specific immunotherapy, Clinical trials methodology in SLIT, Efficacy of SLIT, Mechanisms of SLIT, Safety of SLIT, Sublingual immunotherapy
dx.doi.org/10.1186/1939-4551-7-6, hdl.handle.net/1765/87788
World Allergy Organization Journal
Department of General Practice

Canonica, G.W, Cox, L, Pawankar, R, Baena-Cagnani, C.E, Blaiss, M.S, Bonini, S, … Yusuf, O.M. (2014). Sublingual immunotherapy: World Allergy Organization position paper 2013 update. World Allergy Organization Journal (Vol. 7). doi:10.1186/1939-4551-7-6