The purpose of this study was to determine whether prediction of the 3D temperature profile for superficial hyperthermia using constant blood perfusion model could be matched to one with a temperature dependent blood perfusion. We compared three different constant blood perfusion scenarios with one temperature dependent blood perfusion using a layered model of biological tissue consisting of skin (2 mm), fat (10 mm) and muscle (108 mm). For all four scenarios the maximum temperature of 43°C was found in the muscle tissue in the close proximity (1-3 mm) of fat layer. Cumulative histograms of temperature versus volume were identical for the region of 100x100x40 mm3 under the applicator aperture for the three constant blood perfusion models. For temperature dependent blood perfusion model, 85 % of the studied region was covered with the temperature equal or higher than 40°C in comparison with 43 % for the constant blood perfusion models. Hence this study demonstrates that constant blood perfusion scenarios cannot be matched to one with a temperature dependent blood perfusion.

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Erasmus MC: University Medical Center Rotterdam

Dřždǎl, T., Togni, P., Víšek, L., & Vrba, J. (2010). Comparison of constant and temperature dependent blood perfusion in temperature prediction for superficial hyperthermia. Radioengineering, 19(2), 281–289. Retrieved from