Objectives Juvenile idiopathic arthritis (JIA) affects bone mineral density (BMD). Dual-energy X-ray absorptiometry (DXA) is the most widely used technique to determine BMD. Digital X-ray radiogrammetry (DXR) is a feasible method for determination of cortical BMD on hand radiographs. This study aimed to compare DXR and DXA in the assessment of BMD in JIA patients. Methods Thirty-five JIA patients with available DXA and hand radiograph within the same time period were included from the Dutch Arthritis and Biologicals in Children register. Outcome measures for BMD were Bone Health Index from DXR and BMD total body, BMD lumbar spine and Bone Mineral Apparent Density from DXA. All measures were transformed to Z-scores. Correlations were assessed with Pearson correlation coefficients. Results Median age of the patients (60% female) was 11.7 years. Pearson correlation coefficient was significant for the absolute scores: 0.568-0.770 (p < 0.001). No significant correlation was found between the Z-scores of DXA and DXR. Conclusions The BMD assessment from the DXR was correlated to DXA measures in a cohort of JIA patients, although only in absolute scores. Future steps for implementation of DXR in clinical practice include evaluation of responsiveness to change, predictive value and comparison with other imaging techniques.

Bone density, Dual-energy X-ray absorptiometry, Etanercept, Juvenile idiopathic arthritis, Radiography
dx.doi.org/10.1016/j.ejrad.2015.06.015, hdl.handle.net/1765/88004
European Journal of Radiology
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Erasmus MC: University Medical Center Rotterdam

Nusman, C.M, Anink, J, Otten, M.H, van Rossum, M.A.J, van Rijn, R.R, Maas, M, & van Suijlekom-Smit, L.W.A. (2015). Bone health of patients with juvenile idiopathic arthritis: A comparison between dual-energy X-ray absorptiometry and digital X-ray radiogrammetry. European Journal of Radiology, 84(10), 1999–2003. doi:10.1016/j.ejrad.2015.06.015