Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called “Heartbeat OCT”, combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one cardiac cycle. We acquired in vivo data sets of two coronary arteries in a porcine heart with both Heartbeat OCT, working at 2.88 MHz A-line rate, 4000 frames/s and 100 mm/s pullback speed, and with a commercial system. The in vivo results show that Heartbeat OCT provides faithfully rendered, motion-artifact free, fully sampled vessel wall architecture, unlike the conventional IV-OCT data. We present the Heartbeat OCT system in full technical detail and discuss the steps needed for clinical translation of the technology.

Endoscopic imaging, Fiber optics imaging, Medical and biological imaging, Medical optics instrumentation, Optical coherence tomography, Scanners, Three-dimensional image acquisition
dx.doi.org/10.1364/BOE.6.005021, hdl.handle.net/1765/88021
Biomedical Optics Express
Erasmus MC: University Medical Center Rotterdam

Wang, T, Pfeiffer, A.F.H, Regar, E.S, Wieser, W, van Beusekom, H.M.M, Lancée, C.T, … van Soest, G. (2015). Heartbeat OCT: In vivo intravascular megahertz-optical coherence tomography. Biomedical Optics Express, 6(12), 5021–5032. doi:10.1364/BOE.6.005021