Hereditary angio-oedema is characterised by recurrent episodes of laryngeal, intra-abdominal, facial or peripheral oedema. Danazol can be used as prophylaxis for recurrent attacks. Hepatotoxicity is a recognised adverse effect of danazol. We report an exceptional case of a danazol-induced hepatocellular carcinoma in a 75-year-old patient with hereditary angio-oedema.

Androgen therapy, Danazol, HCC, Hepatocellular carcinoma, Hereditary angio-oedema
The Netherlands Journal of Medicine
Department of Surgical Oncology

Berkel, A.E.M, Bouman, D.E, Schaafsma, M.R, Verhoef, C, & Klaase, J.M. (2014). Hepatocellular carcinoma after danazol treatment for hereditary angio-oedema. The Netherlands Journal of Medicine, 72(7), 380–382. Retrieved from