Hereditary angio-oedema is characterised by recurrent episodes of laryngeal, intra-abdominal, facial or peripheral oedema. Danazol can be used as prophylaxis for recurrent attacks. Hepatotoxicity is a recognised adverse effect of danazol. We report an exceptional case of a danazol-induced hepatocellular carcinoma in a 75-year-old patient with hereditary angio-oedema.

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hdl.handle.net/1765/88082
The Netherlands Journal of Medicine
Department of Surgical Oncology

Berkel, A., Bouman, D. E., Schaafsma, M., Verhoef, K., & Klaase, J. (2014). Hepatocellular carcinoma after danazol treatment for hereditary angio-oedema. The Netherlands Journal of Medicine, 72(7), 380–382. Retrieved from http://hdl.handle.net/1765/88082