2015
NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias
Publication
Publication
Leukemia Research: clinical and laboratory studies , Volume 39 - Issue 7 p. 769- 772
We assessed lineage involvement by NUP98 translocations in myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML), and T-cell acute lymphoblastic leukaemia (T-ALL). Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that, despite diverse partners, i.e. NSD1, DDX10, RAP1GDS1, and LNP1, NUP98 translocations always affected a CD34+/CD133+ hematopoietic precursor. Interestingly the abnormal clone included myelomonocytes, erythroid cells, B- and T- lymphocytes in MDS/AML and only CD7+/CD3+ cells in T-ALL. The NUP98-RAP1GDS1 affected different hematopoietic lineages in AML and T-ALL. Additional specific genomic events, were identified, namely FLT3 and CEBPA mutations in MDS/AML, and NOTCH1 mutations and MYB duplication in T-ALL.
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| doi.org/10.1016/j.leukres.2015.04.014, hdl.handle.net/1765/88385 | |
| Leukemia Research: clinical and laboratory studies | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Crescenzi, A., Nofrini, V., Barba, G., Matteucci, D., Di Giacomo, D., Gorello, P., … Mecucci, C. (2015). NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias. Leukemia Research: clinical and laboratory studies, 39(7), 769–772. doi:10.1016/j.leukres.2015.04.014 |
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