Objective: To investigate the genetic determinants for developing tuberculosis in Sudan. Methods: Case study of 232 patients with tuberculosis and 206 healthy matched controls from Sudan. In the study population, three single nucleotide polymorphisms (SNPs) in the promoter regions of CCL5 and two in the promoter region of IL-10 were genotyped using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). These five SNPs influence the expression of these genes. Results: There were significant differences in allele distribution for CCL5 -28 C/G (rs 2280788) and IL-10 -592 A/C (rs1800872) in patients with tuberculosis compared with healthy controls. Conclusion: This indicates that the genotypes obtained for CCL5 and IL-10 are associated with an increased risk of developing active TB.

Mycobacterium, PCR-RFLP, Susceptibility, TB
dx.doi.org/10.1111/tmi.12141, hdl.handle.net/1765/88610
Tropical Medicine & International Health
Erasmus MC: University Medical Center Rotterdam

Mhmoud, N.A, Fahal, A.H, & van de Sande, W.W.J. (2013). Association of IL-10 and CCL5 single nucleotide polymorphisms with tuberculosis in the Sudanese population. Tropical Medicine & International Health, 18(9), 1119–1127. doi:10.1111/tmi.12141