Objectives: The purpose of this study is to evaluate the long-term health related quality of life (HRQoL) in a cohort of children surgically treated for laryngotracheal stenosis (LTS). Study design: Prospective cohort study. Methods: Parents of children between 4 and 18 years at follow-up completed the Child Health Questionnaire Parent Form (CHQ-PF50). Children between 11 and 18 years at follow-up completed the Child Health Questionnaire Child Form (CHQ-CF87). Biographical and pre-operative data were extracted from the hospital records. Post-operative measurements consisted of the Bruce treadmill test and pulmonary function testing (PFT). Results: Fifty-four parents completed the CHQ-PF50; twenty-one children completed the CHQ-CF87. The CHQ-PF50 was significantly worse than the norm population on the subscales physical functioning, role functioning: emotional/behavior, general health perceptions, family activities, parental impact: emotional, and time. CHQ-CF87 was significantly worse than the norm population on physical functioning and better on mental health. After multivariate analysis, presence of co-morbidities and glottic stenosis are the most important pre-operative factors for worse scores on general health. As post-operative measurements, the Bruce treadmill test and peak expiratory flow (PEF) correlate well with HRQoL physical subscales. Conclusions: At long-term follow-up after treatment for LTS, deficits in HRQoL may still exist. Presence of co-morbidities and glottic stenosis are important negative factors for long-term HRQoL. The Bruce treadmill test and peak expiratory flow on pulmonary function testing correlate well with physical subscales on HRQoL. A long-term multidisciplinary follow-up with assessment of HRQoL is advised in patients treated for LTS.

Additional Metadata
Keywords Children, Cricotracheal resection, Health related quality of life, Laryngotracheal reconstruction, Laryngotracheal stenosis, Surgical results
Persistent URL dx.doi.org/10.1016/j.ijporl.2016.02.008, hdl.handle.net/1765/88697
Journal International Journal of Pediatric Otorhinolaryngology
Citation
Pullens, B, Dulfer, K, Buysse, C.M.P, Hoeve, L.J, Timmerman, M.K, & Joosten, K.F.M. (2016). Long-term quality of life in children after open airway surgery for laryngotracheal stenosis. International Journal of Pediatric Otorhinolaryngology, 84, 88–93. doi:10.1016/j.ijporl.2016.02.008