Since the introduction of the bivalent human papilloma virus (HPV) vaccine in the Netherlands, migraine has been reported as a notable event in the passive safety surveillance system. Research on the association between HPV vaccination and migraine is needed. Therefore, potential migraine cases in 2008–2010 were selected from a group of general practitioners and linked to the vaccination registry. Data were analysed in three ways: (i) incidences of migraine postvaccination (2009/2010) were compared to pre-vaccination incidences (2008); (ii) in a cohort, incidence rates of migraine in vaccinated and unvaccinated girls were compared and (iii) in a self-controlled case series analysis, the relative incidence of migraine in potentially high-risk periods was compared to non-high-risk periods. Incidence rates of migraine for 12- to 16-year-old girls and boys postvaccination were slightly higher than pre-vaccination incidence rates. Incidence rate ratios (IRRs) for vaccinated compared to unvaccinated girls were not statistically significantly higher. Furthermore, the RR for migraine in the high-risk period of 6 weeks following each dose versus non-high-risk period was 4.3 (95% confidence interval (CI) 0.69–26.6) for certain migraine. Conclusion: Using different methods, no statistically significant association between HPV vaccination and incident migraine was found. However, the number of cases was low; to definitively exclude the risk, an increased sample size is needed.

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doi.org/10.1007/s00431-014-2444-x, hdl.handle.net/1765/88756
European Journal of Pediatrics
Erasmus MC: University Medical Center Rotterdam

Klooster, T.M.S.-V, de Ridder, M.A.J, Kemmeren, J.M, van der Lei, J, Dekker, F.W, Sturkenboom, M.C.J.M, & de Melker, H.E. (2015). Examining a possible association between human papilloma virus (HPV) vaccination and migraine: results of a cohort study in the Netherlands. European Journal of Pediatrics, 174(5), 641–649. doi:10.1007/s00431-014-2444-x