Current approach to intravascular volume optimization is made from a macrohemodynamic perspective. However, several situations wherein macrocirculatory and microcirculatory coherence is lost have been described. Future clinical trials should explore the usefulness of integrating the microcirculatory evaluation in fluid optimization.

Fluid therapy, Goal-directed therapy, Hypovolemia, Microcirculation, Shock,
Current Opinion in Critical Care
Department of Intensive Care

Gruartmoner, G, Mesquida, J, & Ince, C. (2015). Fluid therapy and the hypovolemic microcirculation. Current Opinion in Critical Care (Vol. 21, pp. 276–284). doi:10.1097/MCC.0000000000000220