Reply to Koleva-Kolarova et al.

Dear editor,
We would like to sincerely thank the authors for their extensive overviewon simulationmodels for breast cancer screening. The multitude of papers cited clearly shows the utility of modelling in predicting harms and benefits of screening scenarios, guiding policy decisions and ultimately quantifying the effects of running programmes. Recent examples include the USPSTF-recommendations on lung, colorectal and breast cancer screening, partially based on CISNET modelling, but also the EU guidelines and IARC statements on (breast) cancer screening include simulation modelevidence. We therefore almost implicitly disagree with the authors' unfounded statement that there is high risk of bias in the model outcomes. [...]