Background This experimental study investigates infectious complications and functional outcome of biological meshes in a contaminated environment. Methods In 90 rats peritonitis was induced, and after 24 hours, a biological mesh was implanted intraperitoneally including 2 non-crosslinked mesh groups (Strattice and Surgisis) and 2 crosslinked mesh groups (CollaMendFM and Permacol). Sacrifice was after 90 and 180 days. Results More mesh infections occurred in crosslinked meshes compared with non-crosslinked meshes (70% vs 4%; P <.001). Mesh infection was the highest in crosslinked CollaMendFM (81.2%) and lowest in non-crosslinked Strattice groups (0%). Incorporation into the abdominal wall was poor in all meshes (0% to 39%). After 180 days no residue of non-crosslinked Surgisis mesh was found. After 180 days, shrinkage was.8% in crosslinked Permacol and 20% in Strattice groups. Strattice showed the least adhesion formation (median 5%). Conclusions Infection rate of biological meshes in a contaminated field was the highest in crosslinked meshes. All biological meshes showed poor incorporation, which makes long-term abdominal wall repair questionable.

Adhesion formation, Biological mesh, Complications, Hernia, Incorporation, Infection
dx.doi.org/10.1016/j.amjsurg.2014.06.025, hdl.handle.net/1765/90265
The American Journal of Surgery
Department of Neuroscience

Mulder, I.M, Deerenberg, E.B, Bemelman, W.A, Jeekel, J.F, & Lange, J.F. (2015). Infection susceptibility of crosslinked and non-crosslinked biological meshes in an experimental contaminated environment. In The American Journal of Surgery (Vol. 210, pp. 159–166). doi:10.1016/j.amjsurg.2014.06.025