Celiac disease is a common condition with a variable presentation, and is frequently not recognized by the physician. Although a glutenfree diet has a positive effect on the health of the celiac patient, prevention would be even more beneficial. In this article we outline the different possibilities for primary and secondary prevention of celiac disease. Results of recent prospective studies show that at this moment primary prevention is not possible, but secondary preventive strategies can be applied to decrease the morbidity associated with this diseaseÍ mass screening is one option. Results of recent studies concerning this topic will be discussed.