Objective: To investigate relations of several circulating chemokines with extent and phenotype of coronary atherosclerosis and with 1-year clinical outcome. Methods: Intravascular ultrasound virtual histology (IVUS-VH) imaging of a coronary artery was performed in 581 patients. Monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), MIP-1β and regulated upon activation normal T cell expressed and secreted (RANTES) were measured in plasma. Results: Higher MCP-1, MIP-1α and lower RANTES were associated with coronary plaque burden. Higher MCP-1, MIP-1α and lower RANTES were associated with the presence of IVUS-VH-derived thin-cap fibroatheroma lesions. RANTES was associated with major adverse cardiac events. Conclusions: RANTES is a promising biomarker that is inversely associated with coronary plaque burden and vulnerability, as well as with death and acute coronary syndrome.

Atherosclerosis, Biomarker, Chemokines, Intravascular ultrasound, Prognosis
dx.doi.org/10.3109/1354750X.2014.957725, hdl.handle.net/1765/90422
Biomarkers
Erasmus MC: University Medical Center Rotterdam

Cheng, J.M, Oemrawsingh, R.M, Akkerhuis, K.M, Garcia-Garcia, H.M, de Boer, S.P.M, Battes, L.C, … Boersma, H. (2014). Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome. Biomarkers, 19(7), 611–619. doi:10.3109/1354750X.2014.957725