Objective: To investigate relations of several circulating chemokines with extent and phenotype of coronary atherosclerosis and with 1-year clinical outcome. Methods: Intravascular ultrasound virtual histology (IVUS-VH) imaging of a coronary artery was performed in 581 patients. Monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), MIP-1β and regulated upon activation normal T cell expressed and secreted (RANTES) were measured in plasma. Results: Higher MCP-1, MIP-1α and lower RANTES were associated with coronary plaque burden. Higher MCP-1, MIP-1α and lower RANTES were associated with the presence of IVUS-VH-derived thin-cap fibroatheroma lesions. RANTES was associated with major adverse cardiac events. Conclusions: RANTES is a promising biomarker that is inversely associated with coronary plaque burden and vulnerability, as well as with death and acute coronary syndrome.

Additional Metadata
Keywords Atherosclerosis, Biomarker, Chemokines, Intravascular ultrasound, Prognosis
Persistent URL dx.doi.org/10.3109/1354750X.2014.957725, hdl.handle.net/1765/90422
Journal Biomarkers
Citation
Cheng, J.M, Oemrawsingh, R.M, Akkerhuis, K.M, Garcia-Garcia, H.M, de Boer, S.P.M, Battes, L.C, … Boersma, H. (2014). Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome. Biomarkers, 19(7), 611–619. doi:10.3109/1354750X.2014.957725