The CyberKnife provides the advantage of allowing fractionated treatment to multiple secondary tumors. This chapter will present the results of published data on this indication. The delivery of precisely targeted radiation doses to secondary lung tumors in a hypofractionated fashion is feasible and safe. Image-guided robotic stereotactic radiosurgery of pulmonary metastases with the CyberKnife achieves good rates of local disease control. The toxicity is limited to the surrounding tissues. In cases of slow growing cancer, SBRT for solitary or oligometastatic tumors may be beneficial for patients.