To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.

doi.org/10.3201/eid1804.110912, hdl.handle.net/1765/90638
Emerging Infectious Diseases - (Open Access)
Erasmus MC: University Medical Center Rotterdam

de Steenwinkel, J.E.M, ten Kate, M.T, de Knegt, G.J, Kremer, K, Aarnoutse, R.E, Boeree, M, … Bakker-Woudenberg, I.A.J.M. (2012). Drug susceptibility of mycobacterium tuberculosis Beijing genotype and association with MDR TB. Emerging Infectious Diseases - (Open Access), 18(4), 660–663. doi:10.3201/eid1804.110912