In recent years, microRNAs (miRNA) have been demonstrated to be present in body fluids and may therefore serve as diagnostic markers for diseases. By characterizing miRNA profiles in plasma, a miRNA signature may potentially be developed as a diagnostic and risk assessment tool for particular (patho)physiological states. This chapter describes the isolation, purification, identification, and sequencing of human plasma miRNAs.

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Department of Internal Medicine

van der Eerden, B.C.J, Alves, R.D.A.M, Kockx, C, Ozgur, Z, Schreuders-Koedam, M, van de Peppel, J, … van Leeuwen, J.P.T.M. (2014). Identification of microRNAs in human plasma. doi:10.1007/978-1-4939-1619-1_7