Background In children with asthma, web-based monitoring and inflammation-driven therapy may lead to improved asthma control and reduction in medications. However, the cost-effectiveness of these monitoring strategies is yet unknown. Objective We assessed the cost-effectiveness of webbased monthly monitoring and of 4-monthly monitoring of FENO as compared with standard care. Methods An economic evaluation was performed alongside a randomised controlled multicentre trial with a 1-year follow-up. Two hundred and seventy-two children with asthma, aged 4-18 years, were randomised to one of three strategies. In standard care, treatment was adapted according to Asthma Control Test (ACT) at 4-monthly visits, in the web-based strategy also according to web-ACT at 1 month intervals, and in the FENO-based strategy according to ACT and FENO at 4- monthly visits. Outcome measures were patient utilities, healthcare costs, societal costs and incremental cost per quality-adjusted life year (QALY) gained. Results No statistically significant differences were found in QALYs and costs between the three strategies. The web-based strategy had 77% chance of being most cost-effective from a healthcare perspective at a willingness to pay a generally accepted €40 000/QALY. The FENO-based strategy had 83% chance of being most cost-effective at €40 000/QALY from a societal perspective. Conclusions Economically, web-based monitoring was preferred from a healthcare perspective, while the FENObased strategy was preferred from a societal perspective, although in QALYs and costs no statistically significant changes were found as compared with standard care. As clinical outcomes also favoured the web-based and FENO-based strategies, these strategies may be useful additions to standard care. Trial registration number Netherlands Trial Register (NTR1995).,
Thorax: an international journal of respiratory medicine
Erasmus MC: University Medical Center Rotterdam

Beerthuizen, T, Voorend-van Bergen, T.A.S, van den Hout, W.B, Vaessen-Verberne, A.A.P.H, Brackel, H.J.L, Landstra, A.M, … Sont, J.K. (2016). Cost-effectiveness of FENO-based and web-based monitoring in paediatric asthma management: A randomised controlled trial. Thorax: an international journal of respiratory medicine, 71(7), 607–613. doi:10.1136/thoraxjnl-2015-207593