The purpose of this review was to identify publications on resection margins in oral cancer surgery and compare these with the results from 2 Dutch academic medical centers. Eight publications were considered relevant for this study, reporting 30% to 65% inadequate resection margins (ie, positive and close margins), compared to 85% in Dutch centers. However, clinical outcome in terms of overall survival and recurrence seemed comparable. The misleading difference is caused by lack of unanimous margin definition and differences in surgicopathological approaches. This prevents comparison between the centers. Data from Dutch centers showed that inadequate resection margins have a significantly negative effect on local recurrence, regional recurrence, distant metastasis, and overall survival. These results confirm the need for improvement in oral cancer surgery. We underline the need for consistent protocols and optimization of frozen section procedures. We comment on development of optical techniques for intraoperative assessment of resection margins.

Additional Metadata
Keywords Head and neck cancer, Mouth neoplasms, Oral cancer, Oral surgery, Squamous cell carcinoma
Persistent URL,
Journal Head & Neck: journal for the sciences and specialities of the head and neck
Smits, R.W.H, Koljenović, S, Hardillo, J.A.U, Ten Hove, I, Meeuwis, C.A, Sewnaik, A, … Baatenburg de Jong, R.J. (2016). Resection margins in oral cancer surgery: Room for improvement. Head & Neck: journal for the sciences and specialities of the head and neck, 38, E2197–E2203. doi:10.1002/hed.24075