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S. van Boheemen (Sander), T. Jones (Terry), B. Muhlemann (Barbara), M.C.W. Feltkamp (Mariet C.W.), R.A.M. Fouchier (Ron) and E. Hajdarbegovic (Enes)

2015

Cidofovir gel as treatment of follicular spicules in multiple myeloma

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Publication

JAMA Dermatology , Volume 151 - Issue 1 p. 82- 84

IMPORTANCE: The cause of follicular spicules in multiplemyeloma (MM) is not known. OBSERVATIONS: We present a case of follicular spicules in a patient with MM, which is very reminiscent of trichodysplasia spinulosa caused by a polyomavirus. No trichodysplasia spinulosa-associated polyomavirus could be isolated from the skin lesions; however, the spicules were positive for Merkel cell carcinoma virus, which is also a polyomavirus. CONCLUSIONS AND RELEVANCE: Follicular spicules in MM are probably not caused by the trichodysplasia spinulosa-associated virus. Merkel cell polyomavirus could contribute to the origin of this dermatosis.

Additional Metadata
Persistent URL doi.org/10.1001/jamadermatol.2014.1616, hdl.handle.net/1765/90860
Journal JAMA Dermatology
Grant This work was funded by the European Commission 7th Framework Programme; grant id fp7/223498 - European management platform for emerging and re-emerging infectious disease entities (EMPERIE), This work was funded by the European Commission 7th Framework Programme; grant id fp7/260644 - Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses (SILVER), This work was funded by the European Commission 7th Framework Programme; grant id fp7/278976 - ANTIcipating the Global Onset of Novel Epidemics (ANTIGONE)
Organisation Department of Dermatology
Citation
van Boheemen, S., Jones, T., Muhlemann, B., Feltkamp, M. C. W., Fouchier, R., & Hajdarbegovic, E. (2015). Cidofovir gel as treatment of follicular spicules in multiple myeloma. JAMA Dermatology, 151(1), 82–84. doi:10.1001/jamadermatol.2014.1616


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