IMPORTANCE: The cause of follicular spicules in multiplemyeloma (MM) is not known. OBSERVATIONS: We present a case of follicular spicules in a patient with MM, which is very reminiscent of trichodysplasia spinulosa caused by a polyomavirus. No trichodysplasia spinulosa-associated polyomavirus could be isolated from the skin lesions; however, the spicules were positive for Merkel cell carcinoma virus, which is also a polyomavirus. CONCLUSIONS AND RELEVANCE: Follicular spicules in MM are probably not caused by the trichodysplasia spinulosa-associated virus. Merkel cell polyomavirus could contribute to the origin of this dermatosis.,
JAMA Dermatology
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Department of Dermatology

van Boheemen, S, Jones, T, Muhlemann, B, Feltkamp, M.C.W, Fouchier, R.A.M, & Hajdarbegovic, E. (2015). Cidofovir gel as treatment of follicular spicules in multiple myeloma. JAMA Dermatology, 151(1), 82–84. doi:10.1001/jamadermatol.2014.1616