IMPORTANCE: The cause of follicular spicules in multiplemyeloma (MM) is not known. OBSERVATIONS: We present a case of follicular spicules in a patient with MM, which is very reminiscent of trichodysplasia spinulosa caused by a polyomavirus. No trichodysplasia spinulosa-associated polyomavirus could be isolated from the skin lesions; however, the spicules were positive for Merkel cell carcinoma virus, which is also a polyomavirus. CONCLUSIONS AND RELEVANCE: Follicular spicules in MM are probably not caused by the trichodysplasia spinulosa-associated virus. Merkel cell polyomavirus could contribute to the origin of this dermatosis.

dx.doi.org/10.1001/jamadermatol.2014.1616, hdl.handle.net/1765/90860
JAMA Dermatology
This work was funded by the European Commission 7th Framework Programme; grant id fp7/223498 - European management platform for emerging and re-emerging infectious disease entities (EMPERIE), This work was funded by the European Commission 7th Framework Programme; grant id fp7/260644 - Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses (SILVER), This work was funded by the European Commission 7th Framework Programme; grant id fp7/278976 - ANTIcipating the Global Onset of Novel Epidemics (ANTIGONE)
Department of Dermatology

van Boheemen, S, Jones, T, Muhlemann, B, Feltkamp, M.C.W, Fouchier, R.A.M, & Hajdarbegovic, E. (2015). Cidofovir gel as treatment of follicular spicules in multiple myeloma. JAMA Dermatology, 151(1), 82–84. doi:10.1001/jamadermatol.2014.1616