Introduction: A common and severe osteoporotic type fracture in older women is a hip fracture. It is not clear whether bone turnover parameters measured in blood can be a useful tool to predict fracture risk in older persons. The aim of the current study was to assess the association between serum vitamin D (25OHD) levels, parathyroid hormone (PTH), total osteocalcin, carboxy-terminal collagen crosslinks (CTX) and hip fractures in older fallers. Material and methods: A single centre, prospective cohort study of bone parameters was carried out in 400 female patients aged > 70 years including 200 with a hip fracture and 200 without fractures, admitted after a fall between January 2005 and December 2007. Results: Serum total osteocalcin levels were significantly lower in the fracture group compared to the non-fracture group (20.4 ng/ml vs 26.1 ng/ml, respectively, p = 0.01). This finding remained significant after exclusion of the patients on bisphosphonates (p = 0.003). There were no significant differences in 25OHD, PTH or CTX levels between the two groups. Conclusion: In the current study there was an association between the presence of a hip fracture and lower total serum osteocalcin concentrations. This could be indicative of low bone turnover osteoporosis in these women. An association for other bone turnover markers was lacking.

Elderly women, Falls, Hip fracture, Osteoporosis, Total osteocalcin
dx.doi.org/10.1007/s00391-014-0843-2, hdl.handle.net/1765/90935
Zeitschrift fur Gerontologie und Geriatrie
Department of Internal Medicine

Thaler, H.W, Oudshoorn, C, Hartholt, K.A, & van der Cammen, T.J.M. (2015). Parameters of bone health and fracture risk in older female fall victims: what do they tell us?. Zeitschrift fur Gerontologie und Geriatrie, 48(6), 539–542. doi:10.1007/s00391-014-0843-2