Variability of aerosol delivery via spacer devices in young asthmatic children in daily life
Pressurized metered dose inhalers (pMDI) are widely used together with spacers for the treatment of asthma in children. However, the variability of daily medication dose for pMDI/spacer combinations is not known. Electrostatic charge is a potential source of dose variability. Metal spacers have no static charge. This study assessed and compared within-subject variability of aerosol delivery of metal and plastic spacers. This was a randomized, crossover study in children with stable asthma aged 1-4 (group I, n=17) and 5-8 (group II, n=16) yrs. In both groups the amount of drug delivered to the mouth by a metal spacer (Nebuchamber) and one of two plastic (polycarbonate) spacers, i.e. Babyhaler in group I and Volumatic in group II was measured. The metal and plastic spacers were tested at home in a randomized order for 7 days each, using budesonide (200 microg b.i.d.). Aerosol was collected on a filter positioned between spacer and facemask or mouth. Budesonide on the filter was assessed by high performance liquid chromatography. The mean filter dose for each child (mean+/-SD) during the 7 days was expressed as a percentage of the nominal dose. Within-subject variability was expressed as coefficient of variation (CV). Mean filter dose in group I was 41.7+/-10.1% for Nebuchamber and 26.0+/-4.0% for Babyhaler (p<0.001). Mean filter dose in group II was 50.2+/-9.2% for Nebuchamber and 19.4+/-7.2% for Volumatic (p<0.001). Mean CV in group I was 34% for Nebuchamber and 37% for Babyhaler (p=0.44). Mean CV in group II was 23% for Nebuchamber and 34% for Volumatic (p=0.003). There was substantial within-subject dose variability in aerosol delivery in children using a pMDI/spacer at home. This variability was lower for the metal than for the plastic spacer in children 5-8 yrs of age. The dose delivered to the mouth was about two-fold higher for the metal than the plastic spacer independent of age.
|*Nebulizers and Vaporizers, Aerosols/*administration & dosage/therapeutic use, Asthma/*drug therapy, Bronchodilator Agents/*administration & dosage/therapeutic use, Budesonide/*administration & dosage/therapeutic use, Child, Child, Preschool, Cross-Over Studies, Drug Delivery Systems, Filtration/instrumentation, Humans, Infant, Masks, Research Support, Non-U.S. Gov't|
|The European Respiratory Journal|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Janssens, H.M, Devadason, S.G, Hop, W.C.J, LeSouef, P.N, de Jongste, J.C, & Tiddens, H.A.W.M. (1999). Variability of aerosol delivery via spacer devices in young asthmatic children in daily life. The European Respiratory Journal. Retrieved from http://hdl.handle.net/1765/9110