Polygenic risk scores for schizophrenia and bipolar disorder predict creativity
Nature Neuroscience , Volume 18 - Issue 7 p. 953- 955
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.
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Power, R.A, Steinberg, S, Bjornsdottir, G, Rietveld, C.A, Abdellaoui, A, Nivard, M.M, … Zwart, J-A. (2015). Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nature Neuroscience, 18(7), 953–955. doi:10.1038/nn.4040