Purpose To develop and validate a method for improving image resolution of late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) for accurate assessment of myocardial scar. Materials and Methods In a cohort of 37 postinfarction patients, LGE was performed prior to ventricular tachycardia catheter ablation therapy at 1.5T. A super-resolution reconstruction (SRR) technique was applied to the three anisotropic views: short-axis (SA), two-chamber, and four-chamber, to reconstruct a single isotropic volume. For compensation of the interscan heart motion, a joint localized gradient-correlation-based scheme was developed. Scar was identified as either core or gray zone in both the SRR and original SA volumes, and evaluated based on the clinically established bipolar voltage range of the in vivo electroanatomical voltage mapping (EAVM). Results Compared to the SA volume, the SRR method resulted in significantly (P<0.05) reduced myocardial scar gray zone sizes (10.5±8.8 g vs. 9.2±8.1 g) and improved agreement of the bipolar voltage range of scar gray zone (0.99±0.65 mV vs. 1.46±1.15 mV). Conclusion We propose an SRR method to automatically reconstruct a high-quality isotropic LGE volume from three orthogonal views. Analysis of the in vivo EAVM demonstrated improved myocardial scar assessment from the SRR volume compared with the SA LGE alone.

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Keywords image registration, late gadolinium-enhanced MR, myocardial scar, super-resolution reconstruction
Persistent URL dx.doi.org/10.1002/jmri.24759, hdl.handle.net/1765/91186
Journal Journal of Magnetic Resonance Imaging
Dzyubachyk, O.M, Tao, Q, Poot, D.H.J, Lamb, H.J, Zeppenfeld, K, Lelieveldt, B.P.F, & van der Geest, R.J. (2015). Super-resolution reconstruction of late gadolinium-enhanced MRI for improved myocardial scar assessment. Journal of Magnetic Resonance Imaging, 42(1), 160–167. doi:10.1002/jmri.24759