Acromegaly: the significance of serum total and free IGF-I and IGF-binding protein-3 in diagnosis
We have studied the physiological and clinical relevance of measurements of serum total and free IGF-I and IGF-binding protein-3 (IGFBP-3) in 57 previously untreated patients with active acromegaly (32 males, 25 females; mean age 47 years) as compared with sex- and age-matched normal healthy controls. Serum total and free IGF-I, but not IGFBP-3, are suitable biochemical parameters for screening for acromegaly. In acromegalics, the mean 24 h serum GH, total IGF-I and IGFBP-3 levels tend to decrease with age. However, in our series of patients, mean 24 h serum GH levels, IGFBP-3, total and free IGF-I do not correlate with disease activity in acromegaly.
|Keywords||Acromegaly/blood/*diagnosis, Biological Markers/blood, Growth Hormone/blood, Insulin-Like Growth Factor Binding Protein 3/*blood, Insulin-Like Growth Factor I/*analysis, aging/blood, female, humans, male, middle aged|
|Journal||Journal of Endocrinology|
van der Lely, A-J, de Herder, W.W, Janssen, J.A.M.J.L, & Lamberts, S.W.J. (1997). Acromegaly: the significance of serum total and free IGF-I and IGF-binding protein-3 in diagnosis. Journal of Endocrinology. Retrieved from http://hdl.handle.net/1765/9120