A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B.

, ,
doi.org/10.1111/myc.12440, hdl.handle.net/1765/91210
Department of Medical Microbiology and Infectious Diseases

Lestrade, P., Meis, J. F., Arends, J., van der Beek, M., de Brauwer, E. I. G. B., van Dijk, K., … Verweij, P. (2016). Diagnosis and management of aspergillosis in the Netherlands: A national survey. Mycoses, 59(2), 101–107. doi:10.1111/myc.12440