A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B.

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doi.org/10.1111/myc.12440, hdl.handle.net/1765/91210
Department of Medical Microbiology and Infectious Diseases

Lestrade, P.P.A, Meis, J.F, Arends, J.P.A, van der Beek, M.T, de Brauwer, E.I.G.B, van Dijk, K, … Verweij, P.E. (2016). Diagnosis and management of aspergillosis in the Netherlands: A national survey. Mycoses, 59(2), 101–107. doi:10.1111/myc.12440