2011-09-14
[New insights into the pathogenesis of pre-eclampsia: the role of angiogenesis-inhibiting factors].
Publication
Publication
Nederlands Tijdschrift voor Geneeskunde , Volume 155
The pathogenesis of pre-eclampsia is biphasic. The first phase is characterised by insufficient placentation and the second phase by an increased placental release of 2 anti-angiogenic factors, namely, soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng). Within maternal circulation, sFlt-1 and sEng inhibit the effects of vascular endothelial growth factor (VEGF) and transforming growth factor β (TGFβ). This results in endothelial cell activation and inflammation, and eventually leads to the clinical syndrome of pre-eclampsia. The rise in plasma concentrations of sFlt-1 and sEng precedes the development of pre-eclampsia with 6-8 weeks. Whether elevations in the plasma concentrations of sFlt and sEng, combined with a decrease in placental growth factor concentrations, can be utilised as a predictor for pre-eclampsia is currently under investigation.
| Additional Metadata | |
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| hdl.handle.net/1765/91255 | |
| Nederlands Tijdschrift voor Geneeskunde | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Verdonk, K., Visser, W., Steegers, E., Kappers, M., Danser, J., & van den Meiracker, A. (2011). [New insights into the pathogenesis of pre-eclampsia: the role of angiogenesis-inhibiting factors].. Nederlands Tijdschrift voor Geneeskunde (Vol. 155). Retrieved from http://hdl.handle.net/1765/91255 |
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