The use of monoclonal antibodies in medicine for in-vivo diagnostic methods and for therapeutic purposes will increase in the future. Although monoclonal antibodies possess a high specificity, the animal origin of these antibodies remains a problem. Repeated administration of animal monoclonal antibodies (in vivo) may induce the formation of human antibodies against these monoclonal antibodies. Because animal monoclonal antibodies are also used in laboratory assays (in vitro), the presence of human antibodies against these animal monoclonal antibodies may cause spuriously elevated or depressed results of these assays. The clinician should be alert to this possibility. A case history is presented to demonstrate the problem.

Antibodies, Monoclonal/*diagnostic use, Calcitonin/blood, Carcinoembryonic Antigen/analysis, False Positive Reactions, Hypersensitivity, Delayed, Multiple Endocrine Neoplasia/blood/*diagnosis, Tumor Markers, Biological/*blood, aged, animals, humans, male, mice
Nederlands Tijdschrift voor Geneeskunde
Erasmus MC: University Medical Center Rotterdam

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