2015-10-20
Within-host and population transmission of blaOXA-48 in K. pneumoniae and E. coli
Publication
Publication
PLoS ONE , Volume 10 - Issue 10
During a large hospital outbreak of OXA-48 producing bacteria, most K. pneumoniaeOXA-48 isolates were phenotypically resistant to meropenem or imipenem, whereas most E. coliOXA-48 isolates were phenotypically susceptible to these antibiotics. In the absence of molecular gene-detection E. coliOXA-48 could remain undetected, facilitating cross-transmission and horizontal gene transfer of blaOXA-48. Based on 868 longitudinal molecular microbiological screening results from patients carrying K. pneumoniaeOXA-48 (n = 24), E. coliOXA-48 (n = 17), or both (n = 40) and mathematical modelling we determined mean durations of colonisation (278 and 225 days for K. pneumoniaeOXA-48 and E. coliOXA-48, respectively), and horizontal gene transfer rates (0.0091/day from K. pneumoniae to E. coli and 0.0015/day vice versa). Based on these findings the maximum effect of horizontal gene transfer of blaOXA-48 originating from E. coliOXA-48 on the basic reproduction number (R0) is 1.9%, and it is, therefore, unlikely that phenotypically susceptible E. coliOXA-48 will contribute significantly to the spread of blaOXA-48. Copyright:
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| doi.org/10.1371/journal.pone.0140960, hdl.handle.net/1765/91487 | |
| PLoS ONE | |
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Haverkate, M. R., Dautzenberg, M. J. D., Ossewaarde, T., van der Zee, A., Den Hollander, J. G., Troelstra, A., … Bootsma, M. (2015). Within-host and population transmission of blaOXA-48 in K. pneumoniae and E. coli. PLoS ONE, 10(10). doi:10.1371/journal.pone.0140960 |
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