To estimate genetic and forensic parameters, the entire mitochondrial DNA control region of 100 unrelated Makrani individuals (males, n=. 96; females, n=. 4) living in Pakistan (Turbat, Panjgur, Awaran, Kharan, Nasirabad, Gwadar, Buleda, Karachi and Burewala) was sequenced. We observed a total of 70 different haplotypes of which 54 were unique and 16 were shared by more than one individual. The Makrani population showed a high genetic diversity (0.9688) and, consequently, a high power of discrimination (0.9592). Our results revealed a strongly admixed mtDNA pool composed of African haplogroups (28%), West Eurasian haplogroups (26%), South Asian haplogroups (24%), and East Asian haplogroups (2%), while the origin of the remaining individuals (20%) could not be confidently assigned. The results of this study are a valuable contribution to build a database of mtDNA variation in Pakistan.

Haplotyping, Hypervariable segment (HVS), Makrani population, Mitochondrial DNA, MtDNA control region, Pakistan,
Legal Medicine
Centre for Rotterdam Cultural Sociology (CROCUS)

Siddiqi, M.H, Akhtar, T, Rakha, A, Abbas, G, Ali, A, Haider, N, … Khan, F.M. (2015). Genetic characterization of the Makrani people of Pakistan from mitochondrial DNA control-region data. Legal Medicine, 17(2), 134–139. doi:10.1016/j.legalmed.2014.09.007