To estimate genetic and forensic parameters, the entire mitochondrial DNA control region of 100 unrelated Makrani individuals (males, n=. 96; females, n=. 4) living in Pakistan (Turbat, Panjgur, Awaran, Kharan, Nasirabad, Gwadar, Buleda, Karachi and Burewala) was sequenced. We observed a total of 70 different haplotypes of which 54 were unique and 16 were shared by more than one individual. The Makrani population showed a high genetic diversity (0.9688) and, consequently, a high power of discrimination (0.9592). Our results revealed a strongly admixed mtDNA pool composed of African haplogroups (28%), West Eurasian haplogroups (26%), South Asian haplogroups (24%), and East Asian haplogroups (2%), while the origin of the remaining individuals (20%) could not be confidently assigned. The results of this study are a valuable contribution to build a database of mtDNA variation in Pakistan.

Haplotyping, Hypervariable segment (HVS), Makrani population, Mitochondrial DNA, MtDNA control region, Pakistan
dx.doi.org/10.1016/j.legalmed.2014.09.007, hdl.handle.net/1765/91605
Legal Medicine
Centre for Rotterdam Cultural Sociology (CROCUS)

Siddiqi, M.H, Akhtar, T, Rakha, A, Abbas, G, Ali, A, Haider, N, … Khan, F.M. (2015). Genetic characterization of the Makrani people of Pakistan from mitochondrial DNA control-region data. Legal Medicine, 17(2), 134–139. doi:10.1016/j.legalmed.2014.09.007