Despite advances in supportive care and novel antifungal agents, mortality caused by invasive Candida infection is high. A 3-year-old boy with disseminated Candida dubliniensis infection during induction chemotherapy for acute lymphoblastic leukemia deteriorated despite resolution of neutropenia and appropriate antifungal treatment. Monocyte human leukocyte antigen-DR expression was extremely low, suggesting immunoparalysis. Adjuvant immunotherapy with interferon-gamma restored the immune response, which was accompanied by clinical and radiographic recovery.

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The Pediatric Infectious Disease Journal
Department of Immunology

Buddingh, E., Leentjens, J., van der Lugt, J., Dik, W., Gresnigt, M. S., Netea, M., … Driessen, G. J. (2015). Interferon-gamma immunotherapy in a patient with refractory disseminated candidiasis. The Pediatric Infectious Disease Journal, 34(12), 1391–1394. doi:10.1097/INF.0000000000000909