Interferon-gamma immunotherapy in a patient with refractory disseminated candidiasis
The Pediatric Infectious Disease Journal , Volume 34 - Issue 12 p. 1391- 1394
Despite advances in supportive care and novel antifungal agents, mortality caused by invasive Candida infection is high. A 3-year-old boy with disseminated Candida dubliniensis infection during induction chemotherapy for acute lymphoblastic leukemia deteriorated despite resolution of neutropenia and appropriate antifungal treatment. Monocyte human leukocyte antigen-DR expression was extremely low, suggesting immunoparalysis. Adjuvant immunotherapy with interferon-gamma restored the immune response, which was accompanied by clinical and radiographic recovery.
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|The Pediatric Infectious Disease Journal|
|Organisation||Department of Immunology|
Buddingh, E.P, Leentjens, J, van der Lugt, J, Dik, W.A, Gresnigt, M.S, Netea, M.G, … Driessen, G.J. (2015). Interferon-gamma immunotherapy in a patient with refractory disseminated candidiasis. The Pediatric Infectious Disease Journal, 34(12), 1391–1394. doi:10.1097/INF.0000000000000909