Despite advances in supportive care and novel antifungal agents, mortality caused by invasive Candida infection is high. A 3-year-old boy with disseminated Candida dubliniensis infection during induction chemotherapy for acute lymphoblastic leukemia deteriorated despite resolution of neutropenia and appropriate antifungal treatment. Monocyte human leukocyte antigen-DR expression was extremely low, suggesting immunoparalysis. Adjuvant immunotherapy with interferon-gamma restored the immune response, which was accompanied by clinical and radiographic recovery.

Candida, immunotherapy, interferon-gamma, leukemia
dx.doi.org/10.1097/INF.0000000000000909, hdl.handle.net/1765/91714
The Pediatric Infectious Disease Journal
Department of Immunology

Buddingh, E.P, Leentjens, J, van der Lugt, J, Dik, W.A, Gresnigt, M.S, Netea, M.G, … Driessen, G.J. (2015). Interferon-gamma immunotherapy in a patient with refractory disseminated candidiasis. The Pediatric Infectious Disease Journal, 34(12), 1391–1394. doi:10.1097/INF.0000000000000909