The choice of topical therapeutics in napkin dermatitis should be based on standardized measures and the relevant underlying aetiological factors. Napkin dermatitis only occurs in those wearing napkins: infants who and incontinent older children and adults. Napkin dermatitis is very common among those who wear napkins. Jordan et al. observed a napkin dermatitis frequency of 50% in a series of 1089 napkin-wearing children. This chapter provides a review of the evidence supporting the various modalities used to manage napkin dermatitis.