Lutein intake at the age of 1 year and cardiometabolic health at the age of 6 years: The Generation R Study
Lutein is a carotenoid with strong antioxidant properties. Previous studies in adults suggest a beneficial role of lutein on cardiometabolic health. However, it is unknown whether this relation also exists in children; therefore, we aimed to assess the relation between lutein intake at 13 months of age and cardiometabolic outcomes at the age of 6 years. We included 2044 Dutch children participating in a population-based prospective cohort study. Diet was measured at 13 months of age with an FFQ. Lutein intake was standardised for energy and β-carotene intake. Blood pressure, anthropometrics, serum lipids and insulin were measured at the age of 6 years. Dual-energy X-ray absorptiometry was performed to measure total and regional fat and lean mass. A continuous cardiometabolic risk factor score was created, including the components body fat percentage, blood pressure, insulin, HDL-cholesterol and TAG. Age- and sex-specific standard deviation scores were created for all outcomes. Multivariable linear regression was performed, including socio-demographic and lifestyle variables. Median (energy-standardised) lutein intake was 1317 mcg/d (95 % range 87, 6069 mcg/d). There were no consistent associations between lutein intake at 13 months and anthropometrics and body composition measures at 6 years of age. In addition, lutein intake was not associated with a continuous cardiometabolic risk factor score, nor was it associated with any of the individual components of the cardiometabolic risk factor score. Results from this large population-based prospective cohort study do not support the hypothesis that lutein intake early in life has a beneficial role for later cardiometabolic health.
|Keywords||Body composition, Cardiometabolic health, Carotenoids, Children, Epidemiology, Lutein|
|Persistent URL||dx.doi.org/10.1017/S0007114515002779, hdl.handle.net/1765/92430|
|Journal||British Journal of Nutrition|
Leermakers, E.T.M, Kiefte-de Jong, J.C, Hofman, A, Jaddoe, V.W.V, & Franco, O.H. (2015). Lutein intake at the age of 1 year and cardiometabolic health at the age of 6 years: The Generation R Study. British Journal of Nutrition, 114(6), 970–978. doi:10.1017/S0007114515002779