Background/Objectives:High Vitamin A intake may be associated with a decreased bone mineral density (BMD) and increased risk of fractures. Our objectives were to study whether dietary intake of Vitamin A (total, retinol or beta-carotene) is associated with BMD and fracture risk and if associations are modified by body mass index (BMI) and Vitamin D.Subjects/Methods:Participants were aged 55 years and older (n=5288) from the Rotterdam Study, a population-based prospective cohort. Baseline Vitamin A and D intake was measured by a food frequency questionnaire. BMD was measured by dual-energy X-ray absorptiometry at four visits between baseline (1989-1993) and 2004. Serum Vitamin D was assessed in a subgroup (n=3161). Fracture incidence data were derived from medical records with a mean follow-up time of 13.9 years.Results:Median intake of Vitamin A ranged from 684 retinol equivalents (REs)/day (quintile 1) to 2000 REs/day (quintile 5). After adjustment for confounders related to lifestyle and socioeconomic status, BMD was significantly higher in subjects in the highest quintile of total Vitamin A (mean difference in BMD (95% confidence interval (CI))=11.53 (0.37-22.7) mg/cm 2) and retinol intake (mean difference in BMD (95% CI)=12.57 (1.10-24.05) mg/cm 2) than in the middle quintile. Additional adjustment for BMI diluted these associations. Fracture risk was reduced in these subjects. Significant interaction was present between intake of retinol and overweight (BMI >25 kg/m 2) in relation to fractures (P for interaction =0.05), but not BMD. Stratified analysis showed that these favourable associations with fracture risk were only present in overweight subjects (BMI >25 kg/m 2). No effect modification by Vitamin D intake or serum levels was observed.Conclusions:Our results suggest a plausible favourable relation between high Vitamin A intake from the diet and fracture risk in overweight subjects, whereas the association between Vitamin A and BMD is mainly explained by BMI.,
European Journal of Clinical Nutrition
Erasmus MC: University Medical Center Rotterdam

de Jonge, E., Kiefte-de Jong, J., Campos Obando, N., Booij, L., Franco, O., Hofman, A., … Zillikens, C. (2015). Dietary Vitamin A intake and bone health in the elderly: The Rotterdam Study. European Journal of Clinical Nutrition, 69(12), 1360–1368. doi:10.1038/ejcn.2015.154